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导师信息
姓名: 高明远 英文名:
 
导师类别: 硕士生导师 所在专业: 食品科学与工程
性别: 最高学位: 博士
所在单位: 中国科学院化学研究所
入职年月: 2017-03-02 出生年月: 2017-03-02
职务: 职称: 研究员
研究方向: 纳米材料生物应用 E-Mail: gaomy@iccas.ac.cn
通讯地址: 中国北京北一街2号中国科学院化学研究所
简历:

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教育经历:

1992.09 - 1995.06   吉林大学化学系高分子专业,博士学位
                             论文题目:纳米微粒在高分子体系中的复合与组装
                             导师:沈家骢院士
1989.09 - 1992.07   吉林大学化学系高分子专业,硕士学位
                             导师:沈家骢院士
1985.09 - 1989.07   吉林大学化学系高分子专业,学士学位

工作经历:

2001.10 - 至今        中国科学院化学研究所,研究员,博士生导师

2001.07 - 2002.01   德国马普胶体界面所,访问学者

1998.09 - 2001.06   德国慕尼黑大学,项目负责人,曾独立承担BMBF项目1项(35万马克)
1996.02 - 1998.08   德国马普胶体界面所,博士后,洪堡学者                             
                             合作导师:Helmuth Moehwald教授

研究成果:

2001年入选中科院“百人计划”,2002年入选德国CIM人才回归计划,同年获国家杰出青年基金,2005年获得“百人计划”终期评估优秀奖,2006年起享受国务院政府津贴,2011年起任973项目首席科学家,2012年至今任基金委专家评审组成员(医学部)。

截止目前,在化学期刊 Chem. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed.,材料学期刊Adv. Mater., Adv. Func. Mater.,综合期刊ACS Nano, Nat. Comm.,生物材料期刊Biomaterials,药学期刊Mol. Pharmaceut.及影像学期刊Magn. Reson. Imaging上共发表学术论文140多篇,累计影响因子总和983.28,影响因子大于10 的论文33 篇,累积引用近9000多次,单篇论文平均引用60次以上;拥有发明专利16项(包括2项美国授权专利);撰写专著2章、1部。2014年获得北京市科学技术奖一等奖(2014 基-1-002)。

先后主持、参与973项目、基金委重大项目、基金委重点项目、基金委重大国际合作项目、863重点项目及基金委面上项目等国家级项目20多项,在国外工作期间曾主持德国的BMBF项目1项。先后组织境内外学术会议10次。培养博士毕业生22名,多名学生在学期间获得包括“中国科学院院长优秀奖”等各类奖项。

获奖情况:

2014                      北京市科学技术一等奖,功能无机纳米颗粒的设计合成与肿瘤体内外检测应用,2014基-01-002  (高明远、李桢、呼凤琴、杨云华、乔瑞瑞、韩伟、巩雁军、雷皓、唐智勇)

2006 - 至今             享受国务院特殊津贴

2005                        中科院“百人计划”终期评估优秀奖

2002                        国家杰出青年基金获得者(化学学部-物理化学)

2002                        德国CIM人才回归计划

2001                        中国科学院“百人计划”入选者

1996                        德国洪堡奖学金(1996年3月25日获批,申请延期4个月执行)

1996                        马普学会奖学金(1996.02 - 1996.07)

1995                        英国皇家学会奖学金,放弃

专利著作:

代表性授权国家发明专利

1. 一种制备具有生物相容性的磁性纳米微粒的方法

2. 一种高结晶度的水分散性磁性纳米微粒的制备方法

3. 高溶解度的水溶磁性纳米晶体及其制备方法

4. 火焰燃烧制备纳米材料的方法

5. 含有碲化镉荧光量子点的二氧化硅荧光微球及其制备方法

6. 一种荧光微球制备方法、荧光微球及其水分散体系

7. 磁性荧光复合材料及制备方法与应用

8. 表面修饰的羧基被活化后的磁性纳米晶体干粉及其制备方法

9. 在生理缓冲液中能够高度溶解并稳定分散的生物相容性磁性纳米晶体及其制备方法

10. 具有生物相容性的放射性核素掺杂的磁性纳米晶体及其制备方法

11. 一种基于上转换荧光/磁性纳米颗粒的免疫层析试纸及其制备方法

12. 含有无机纳米微粒的聚合物微球及其制备方法和用途

论文发表:

1. Tumor Microenvironment-Triggered Aggregation of Anti-Phagocytosis 99mTc-Labelled Fe3O4 Nanoprobes for Enhanced Tumor Imaging in Vivo, Zhenyu Gao#, Yi Hou#, Jianfeng Zeng, Lei Chen, Chunyan Liu, Wensheng Yang*, and Mingyuan Gao*, Adv. Mater., 2017, DOI:10.1002/adma.201701095

2. Diverse Applications of Nanomedicine, Beatriz Pelaz, Christoph Alexiou, Ramon A. Alvarez Puebla, Frauke Alves, Anne M. Andrews, Sumaira Ashraf, Lajos P. Balogh, Laura Ballerini, Alessandra Bestetti, Cornelia Brendel, et al., ACS Nano2017, DOI: 10.1021/acsnano.6b06040.

3. Nanopolymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray computed Tomography Imaging In Vivo, Yan Zou, Yaohua Wei, Guanglin Wang, Fenghua Meng,* Mingyuan Gao, Gert Storm, and Zhiyuan Zhong*, Adv. Mater., 2017, DOI:10.1002/adma.201603997.

4. Molecular Imaging of Vulnerable Atherosclerotic Plaques In Vivo with Osteopontin-Specific Upconversion Nanoprobes, Ruirui Qiao‡, Hongyu Qiao‡, Yan Zhang, Yabin Wang, Chongwei Chi, Jie Tian, Lifang Zhang, Feng Cao*, and Mingyuan Gao*, ACS Nano2017, 11(2), 1816-1825.

5. Light-triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo, Xiaju Cheng, Rui Sun, Ling Yin, Zhifang Chai, Haibin Shi*, and Mingyuan Gao*, Adv. Mater.2017, DOI: 10.1002/adma.201604894. (cover)

6. Ultrasmall Biocompatible Bi2Se3 Nanodots for Multimodal Imaging-Guided Synergistic Radiophotothermal Therapy against Cancer, Fangxin Mao, Ling Wen ; Caixia Sun, Shaohua Zhang, Guanglin Wang, Jianfeng Zeng, Yong Wang, Jianmin Ma, Mingyuan Gao, Zhen Li, ACS Nano, 2016, 10(12), 11145-11155

7. Aqueous Based Semiconductor Nanocrystals, Lihong Jing‡, Stephen V. Kershaw‡, Yilin Li, Xiaodan Huang, Yingying Li, Andrey L. Rogach*, and Mingyuan Gao*, Chem. Rev.2016116(18), 10623-10730.

8. Ambient Aqueous Synthesis of Ultra-small PEGylated Cu2-xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer, Shaohua Zhang, Caixia Sun, Jianfeng Zeng, Guanglin Wang, Yong Wang, Qiao Sun, Yan Wu, Mingyuan Gao, Zhen Li*, Shixue Dou*, Adv. Mater.201628(40), 8927-8936, (cover)                       

9. BSA-Mediated Synthesis of Bismuth Sulfide Nanotheranostic Agents for Tumor Multimodal Imaging and Thermoradiotherapy, Yong Wang, Yongyou Wu, Yujing Liu, Jia Shen, Ling Lv, Liubing Li, Liecheng Yang, Jianfeng Zeng, Yangyun Wang, Leshuai W. Zhang*, Zhen Li*, Mingyuan Gao*, Zhifang Chai, Adv. Funct. Mater.201626(29), 5335-5344.

10. Ultrasmall Biocompatible WO3-x Nanodots for Multi-modality Imaging and Combined Therapy of Cancers, Ling Wen, Ling Chen, Shimin Zheng, Jianfeng Zeng, Guangxin Duan, Yong Wang, Guanglin Wang, Zhifang Chai, Zhen Li*, Mingyuan Gao*, Adv. Mater.201628(25), 5072-5079.

11. Generation, Characterization, and Application of Hierarchically Structured Self-assembly Induced by the Combined Effect of Self-emulsification and Phase Separation, Xiuyu Wang, Yi Hou, Li Yao*, Mingyuan Gao*, Maofa Ge, J. Am. Chem. Soc.2016138(7), 2090–2093.

12. In vivo Covalent Cross-Linking of Photo-converted Rare-Earth Nanostructures for Tumor Localization and Theranostic, Xiangzhao Ai, Chris Jun Hui Ho, Junxin Aw, Amalina Binte Ebrahim Attia, Jing Mu, Yu Wang, Xiaoyong Wang, Yong Wang, Xiaogang Liu, Huabing Chen, Mingyuan Gao, Xiaoyuan Chen, Edwin K. L. Yeow, Gang Liu*, Malini Olivo*, Bengang Xing*, Nat. Commun.20167, 10432.

13. Protease-Activated Ratiometric Fluorescent Probe for pH Mapping of Malignant Tumors, Yi Hou, Jin Zhou, Zhenyu Gao, Xiaoyu Sun, Chunyan Liu, Dihua Shangguan, Wensheng Yang, and Mingyuan Gao*, ACS Nano20159(3), 3199–3205.

14. Ultrasensitive in Vivo Detection of Primary Gastric Tumor and Lymphatic Metastasis Using Upconversion Nanoparticles, Ruirui Qiao‡, Changhao Liu‡, Muhan Liu, Hao Hu, Chunyan Liu, Yi Hou, Kaichun Wu*, Yenan Lin, Jimin Liang, Mingyuan Gao*, ACS Nano20159(2), 2120–2129.

15. Insight into Strain Effects on Band Alignment Shifts, Carrier Localization and Recombination Kinetics in CdTe/CdS Core/Shell Quantum Dots, Lihong Jing‡, Stephen V. Kershaw‡, Tobias Kipp‡, Sergii Kalytchuk, Ke Ding, Jianfeng Zeng, Mingxia Jiao, Xiaoyu Sun, Alf Mews, Andrey L. Rogach, and Mingyuan Gao*. J. Am. Chem. Soc., 2015137(5), 2073–2084.

16. Magnetically Engineered Semiconductor Quantum Dots as Multimodal Imaging Probes, Lihong Jing, Ke Ding, Stephen V. Kershaw, Ivan M. Kempson, Andrey L. Rogach*, and Mingyuan Gao*, Adv. Mater., 2014, 26(37), 6367-6386.

17. Are Rare-Earth Nanoparticles Suitable for In Vivo Applications? Chunyan Liu, Yi Hou, and Mingyuan Gao*, Adv. Mater., 2014, 26(40), 6922-6932.

18. Anchoring Group Effects of Surface Ligand on Magnetic Properties of Fe3O4 Nanoparticles: Towards High Performance MRI Contrast Agents, Jianfeng Zeng, Lihong Jing, Yi Hou, Mingxia Jiao, Ruirui Qiao, Qiaojuan Jia, Chunyan Liu, Fang Fang, Hao Lei, and Mingyuan Gao*, Adv. Mater., 2014, 26(17), 2694-2698.

19. Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo, Chunyan Liu, Zhenyu Gao, Jianfeng Zeng, Yi Hou*, Fang Fang, Yilin Li, Ruirui Qiao, Lin Shen, Hao Lei, Wensheng Yang, and Mingyuan Gao*, ACS Nano, 2013, 7(8), 7227-7240.

20. NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts In Vivo, Yi Hou, Ruirui Qiao, Fang Fang, Xuxia Wang, Chengyan Dong, Kan Liu, Chunyan Liu, Zhaofei Liu, Hao Lei*, Fan Wang, and Mingyuan Gao*, ACS Nano, 2013, 7(1), 330-338.

21. Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood-Brain Barrier, Ruirui Qiao, Qiaojuan Jia, Sabine Hüwel, Rui Xia, Ting Liu, Fabao Gao*, Hans-Joachim Galla*, and Mingyuan Gao*
ACS Nano, 2012, 6(4), 3304-3310.

22. Gelification – an Effective Measure for Achieving Differently Sized Biocompatible Fe3O4 Nanocrystals through a Single Preparation Recipe, Qiaojuan Jia, Jianfeng Zeng, Ruirui Qiao, Lihong Jing, Liang Peng, Fenglong Gu*, and Mingyuan Gao*, J. Am. Chem. Soc., 2011, 133(48), 19512-19523.

23. Polyhedral Maghemite Nanocrystals Prepared by a Flame Synthetic Method: Preparations, Characterizations and Catalytic Properties, Nan Zhao, Wei Ma, Zhimin Cui, Weiguo Song, Chuanlai Xu,* and Mingyuan Gao*, ACS Nano, 2009, 3(7), 1775-1780.

24. Magnetic Janus Particles Prepared by a Flame Synthetic Approach: Synthesis, Characterizations and Properties, Nan Zhao, Mingyuan Gao*, Adv. Mater., 2009, 21, 184-187.

25. Synthesis and Shape-tailoring of the Copper Sulfide/Indium Sulfide-Based Nanocrystals, Wei Han, Luoxin Yi, Nan Zhao, Aiwei Tang, Mingyuan Gao*, Zhiyong Tang*, J. Am. Chem. Soc., 2008, 130, 13152-13161.

26. Diameter-Tunable CdTe Nanotubes Templated by 1D Nanowires of Cadmium Thiolate Polymer, Haijun Niu, Mingyuan Gao, Angewandte Chemie Int. Ed., 2006, 45, 6462-6466. (VIP, Inside Cover)

27. Preparations of Biocompatible Magnetite Nanocrystals for In Vivo Magnetic Resonance Detection of Cancer, Fengqin Hu, Li Wei, Zhuan Zhou, Yuliang Ran, Zhen Li, Mingyuan Gao*, Adv. Mater., 2006, 18, 2553-2556.

28. Preparation of Fluorescent SiO2 Particles with Single CdTe Nanocrystal Cores by the Reverse Microemulsion Method, Yunhua Yang, Mingyuan Gao*, Adv. Mater., 2005, 17, 2354-2357.

29. One-pot Reaction to Synthesize Biocompatible Magnetite Nanoparticles, Zhen Li, Li Wei, Mingyuan Gao*, Hao Lei*, Adv. Mater., 2005, 17(8), 1001-1005. (Frequently accessed article)

30. Fabrication of Multicolor Fluorescent Microspheres by Loading CdTe Nanocrystals within Microgel Spheres, Min Kuang, Dayang Wang*, Haobo Bao, Mingyuan Gao*, Helmuth Möhwald and Ming Jiang, Adv. Mater., 2005, 17(3), 267-270.

31. Preparation of Water-soluble Magnetite Nanocrystals by Refluxing Ferric Hydrated Salts in 2-Pyrrolidone: Mechanism Leading to Fe3O4, Zhen Li, Qiao Sun, Mingyuan Gao*, Angew. Chem. Int. Ed., 2005, 44, 123-126.

32. From Water-Soluble CdTe Nanocrystals to Fluorescent Nanocrystal–Polymer Transparent Composites Using Polymerizable Surfactants, Hao Zhang, Zhanchen Cui, Xiulei Ji, Yao Wang, Lianghai Hu, Changli Lü, Bai Yang*, and Mingyuan Gao*, Adv. Mater., 2003, 15(10), 777-780.

33. White light electroluminescence from self-assembled Q-CdSe/PPV multilayer structure, Mingyuan Gao, Bernd Richter, Stefan Kirstein, Adv. Mater., 1997, 9, 802-805.

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